Fig. 2: Preparation of chiral Fe-CPDs and the catalytic asymmetric hydrogenation of acylsilane. | Nature Communications

Fig. 2: Preparation of chiral Fe-CPDs and the catalytic asymmetric hydrogenation of acylsilane.

From: Rationally designed Fe-cyclopentadienone with unique orientations for efficient asymmetric hydrogenation of acylsilanes

Fig. 2: Preparation of chiral Fe-CPDs and the catalytic asymmetric hydrogenation of acylsilane.The alternative text for this image may have been generated using AI.

a Synthetic route for the Fe-CPDs, reaction conditions: (i) Dimethyl (1-diazo-2-oxopropyl)phosphonate, K2CO3, MeOH. (ii) TFA, DCM; then RSO2Cl, NEt3. (iii) LDA, 1,3-diiodopropane/1,4-diiodobutane, THF. (iv) Fe2(CO)9, toluene, reflux. b asymmetric hydrogenation of 1a, reaction conditions: 1a (0.2 mmol), [Fe] (2 mol %), Me₃NO (4 mol %), toluene (0.3 mL), H2 (30 atm), 80 °C, 12 h. ai-PrOH/H2O (0.48: 0.12 mL), 60 °C.

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