Table 2 Participant characteristics before and after ART initiation in various subgroups of HIV controllers
From: Longitudinal plasma proteomic signatures of elite and viremic spontaneous HIV controllers
EC_Persistent | VC_Persistent | VC_Transient | |||||||
|---|---|---|---|---|---|---|---|---|---|
Pre-ART | Post-ART | P value | Pre-ART | Post-ART | P value | Pre-ART | Post-ART | P value | |
(N = 9) | (N = 9) | (N = 57) | (N = 57) | (N = 36) | (N = 36) | ||||
Age | |||||||||
Median [IQR] | 49.5 [35.8, 54.9] | 60.2 [46.9, 63.7] | 0,003 | 39.7 [32.7, 45.7] | 46.9 [43.7, 56.6] | < 0.0001 | 42.6 [35.0, 49.1] | 52.1 [44.2, 60.3] | < 0.0001 |
Sex | |||||||||
Female | 2 (22.2%) | 17 (29.8%) | 9 (25.0%) | ||||||
Male | 7 (77.8%) | 40 (70.2%) | 27 (75.0%) | ||||||
BMI | |||||||||
Median [IQR] | 25.5 [23.7, 27.7] | NA | 24.7 [22.9, 27.2] | NA | 24.3 [22.9, 26.7] | NA | |||
Missing | 1 (11.1%) | 9 (100%) | 11 (19.3%) | 57 (100%) | 5 (13.9%) | 36 (100%) | |||
Smoking status | |||||||||
No | 3 (33.3%) | 4 (44.4%) | ns | 27 (47.4%) | 33 (57.9%) | ns | 17 (47.2%) | 22 (61.1%) | ns |
Yes | 5 (55.6%) | 4 (44.4%) | 27 (47.4%) | 20 (35.1%) | 15 (41.7%) | 10 (27.8%) | |||
Missing | 1 (11.1%) | 1 (11.1%) | 3 (5.3%) | 4 (7.0%) | 4 (11.1%) | 4 (11.1%) | |||
Ethnicity | |||||||||
Asian | 1 (11.1%) | 0 (0%) | 0 (0%) | ||||||
Black | 1 (11.1%) | 21 (36.8%) | 8 (22.2%) | ||||||
Hispanic | 0 (0%) | 1 (1.8%) | 0 (0%) | ||||||
Mixed | 0 (0%) | 1 (1.8%) | 1 (2.8%) | ||||||
White | 5 (55.6%) | 24 (42.1%) | 25 (69.4%) | ||||||
Missing | 2 (22.2%) | 10 (17.5%) | 2 (5.6%) | ||||||
CD4 at sampling (cells/μl) | |||||||||
Median [IQR] | 950.0 [600.0, 1140.0] | 1059.0 [898.0, 1175.5] | ns | 530.0 [430.0, 690.0] | 652.0 [506.0, 850.0] | 0,0008 | 615.0 [527.5, 847.5] | 819.5 [679.0, 937.2] | 0,01 |
Missing | - | 2 (22.2%) | - | - | - | - | |||
CD4 nadir (cells/μl) | |||||||||
Median [IQR] | 600.0 [570.0, 1080.0] | 470.0 [360.0, 620.0] | 545.0 [418.0, 752.5] | ||||||
VL at sampling (copies/mL) | |||||||||
Median [IQR] | 0.0 [0.0, 101.0] | 0.0 [0.0, 0.0] | ns | 1690.0 [662.0, 3000.0] | 0.0 [0.0, 0.0] | < 0.0001 | 2175.0 [606.5, 6590.0] | 0.0 [0.0, 0.0] | < 0.0001 |
HIV duration pre-ART (years) | |||||||||
Median [IQR] | 7.1 [1.3, 8.0] | 5.4 [2.1, 7.0] | 5.3 [2.2, 7.6] | ||||||
ART duration (days) | |||||||||
Median [IQR] | 1120.0 [930.0, 1912.0] | 1952.0 [1080.0, 2940.0] | 1972.5 [1230.0, 2914.8] | ||||||
INSTI | |||||||||
No | 3 (33.3%) | 23 (40.4%) | 19 (52.8%) | ||||||
Yes | 6 (66.7%) | 34 (59.6%) | 17 (47.2%) | ||||||
NNRTI | |||||||||
No | 7 (77.8%) | 39 (68.4%) | 19 (52.8%) | ||||||
Yes | 2 (22.2%) | 18 (31.6%) | 17 (47.2%) | ||||||
PI | |||||||||
No | 8 (88.9%) | 52 (91.2%) | 33 (91.7%) | ||||||
Yes | 1 (11.1%) | 5 (8.8%) | 3 (8.3%) | ||||||
Sample storage (days) | |||||||||
Median [IQR] | 3909.0 [3027.0, 4083.0] | 722.0 [682.0, 872.0] | 0,003 | 4209.0 [3361.0, 5499.0] | 759.0 [681.0, 856.0] | < 0.0001 | 4818.5 [4164.8, 5316.5] | 695.0 [645.5, 815.8] | < 0.0001 |
CENTER | |||||||||
EMC | 1 (11.1%) | 19 (33.3%) | 8 (22.2%) | ||||||
LUMC | 0 (0%) | 3 (5.3%) | 1 (2.8%) | ||||||
MSZ | 2 (22.2%) | 7 (12.3%) | 0 (0%) | ||||||
OLVG | 5 (55.6%) | 21 (36.8%) | 23 (63.9%) | ||||||
RAD | 1 (11.1%) | 4 (7.0%) | 0 (0%) | ||||||
UMCU | 0 (0%) | 3 (5.3%) | 4 (11.1%) | ||||||
