Fig. 3: Substrate scope of aryl diazonium salts and arylboronic acids. | Nature Communications

Fig. 3: Substrate scope of aryl diazonium salts and arylboronic acids.

From: Palladium-catalyzed asymmetric migratory diarylation of unactivated directing-group-free internal alkenes

Fig. 3: Substrate scope of aryl diazonium salts and arylboronic acids.

Reaction conditions: alkene 1 (1.0 equiv, 0.20 mmol), aryl diazonium salt 2 (2.0 equiv, 0.40 mmol), arylboronic acid 3 (3.0 equiv, 0.60 mmol), [Pd(allyl)Cl]2 (2.5 mol %, 0.005 mmol), L3 (10 mol %, 0.02 mmol), A5 (16 mol %, 0.032 mmol), and Ag2CO3 (1.0 equiv, 0.20 mmol) in DME/1,4-Dioxane (0.4 mL (v/v = 1/3), 0.5 M) at 25 oC. Isolated yields were reported and the ee values were determined by chiral HPLC. aDCM/1,4-Dioxane (0.4 mL (v/v = 1/3), 0.5 M) was used.

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