Fig. 5: Negative correlation between population activity and replay step size, and their relationship with slow-gamma oscillations.
From: Dynamical modulation of hippocampal replay through firing rate adaptation
a The CAN model predicts a negative correlation between neural activity and replay step size. Left: scatter plot showing summed Poisson spike counts (across all neurons within the time window used to calculate each step size) versus replay step size. Each dot represents a sampled step from simulated replay trajectories across different FRA strengths. Right: box plot of population firing rate versus binned step size. Orange lines indicate mean values, boxes represent the inter-quartile range, and whiskers denote non-outlier extremes. b Negative correlation between replay step size (time bin = 20 ms) and neural activity in empirical data. c Anti-phase locking of population firing rate (top) and replay step size (middle) with an external oscillation signal (bottom) in the CAN. Red dots mark troughs and peaks of firing rate and step size, respectively; dashed lines mark oscillation troughs. d Population activity (top) and step size (bottom) plotted as a function of oscillation phase in the CAN (two repeated cycles shown). e Normalised contour plots with circular weighted means (arrows) for neural activity (red) and step size (blue) as functions of oscillation phase.
