Fig. 4: 2BAct extends lifespan, partially rescues oligodendrocyte death and demyelination of Jimpy mice. | Nature Communications

Fig. 4: 2BAct extends lifespan, partially rescues oligodendrocyte death and demyelination of Jimpy mice.

From: Integrated stress response inhibition prolongs the lifespan of a Pelizaeus-Merzbacher disease mouse model by increasing oligodendrocyte survival

Fig. 4

a Kaplan–Meier survival curve showing the overall survival of Jimpy mice with control diet (n = 17) and 2BAct diet (n = 13). ****p < 0.0001 indicating statistically significant change between two groups, using Log-rank (Mantel–Cox) test. b Average survival days of two treatment groups. ****p < 0.0001. c Representative images of ASPA staining of corpus callosum from four groups at PND 19: WT mice + control diet, WT mice + 2BAct diet, Jimpy mice + control diet and Jimpy mice + 2BAct diet. d Representative EM images of axons in corpus callosum from four groups at PND19. e Quantification of the number of ASPA+ oligodendrocytes in corpus callosum (n = 5 mice/group). p < 0.0001 (WT+Ctrl vs Jimpy+Ctrl), p = 0.0006 (Jimpy+Ctrl vs Jimpy+2BAct). f Quantification of the number of myelinated axons in corpus callosum (n = 4 mice/WT+Ctrl, 3 mice/WT+2BAct, 4 mice/Jimpy+Ctrl, 5 mice/Jimpy+2BAct). p = 0.0008 (WT+Ctrl vs Jimpy+Ctrl), p = 0.0013 (Jimpy+Ctrl vs Jimpy+2BAct). Values are mean ± SEM. ns - non-significant, **p < 0.01, ***p < 0.001, ****p < 0.0001. Groups were compared using two-tailed unpaired Welch’s t-test. Source data are provided as a Source Data file.

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