Fig. 3: Altered bursting of trisomy 21 neurons.
From: Synaptic and intrinsic membrane defects disrupt early neural network dynamics in Down syndrome
A Pie charts showing that all disomic (D21) cells had bursts in Mg2+-free saline but around a third of trisomic (T21) cells did not. B Representative traces of membrane bursts of D21 and T21 cells in Mg2+-free saline. Introduction of Mg2+ saline abolishes bursts but not EPSCs (insets). C–F Lower bursting rate (C), burst amplitude (D), burst charge transfer (E) and altered burst kinetics (F) of T21 neurons compared to D21 cells. n = 17–43 cells have been depicted in brackets along with p values on graphs; two-tailed unpaired t-test or Mann-Whitney test. Box plots in (C, D) depict median, 25–75% interquartile range and 2–95% whiskers. Bar chart E depicts means +/- SEM.
