Fig. 4: Spike firing anomalies due to trisomy 21.
From: Synaptic and intrinsic membrane defects disrupt early neural network dynamics in Down syndrome
A Resting membrane potential of disomic (D21) and trisomic (T21) neurons. B Rheobase of D21 and T21 neurons. C Spike outputs elicited by injecting depolarising steps of currents as increments of rheobase (rheo). D Input-output relationships of spikes and current injection. E Threshold potential at which neurons fire action potentials at rheobase. F Current at which maximum spikes are elicited in a step protocol of fixed current increments. G Average latency of first spike for the rheobase step current injection protocol. H Example of spike jitter traces and average spike jitter at rheobase for D21 (n = 65) and T21 (n = 54) cells. I–M Average action potential waveform (I), peak potential (J), area (K), rise time (L) and T50 (M) of D21 and T21 spikes at rheobase. n = 54-112 cells. *P < 0.05, **P < 0.01, ***P < 0.001, two-tailed unpaired t-test or Mann-Whitney test. Here, box plots show the median, 25–75% interquartile range and 2–95% whisker and the bar chart depicts means +/- SEM.
