Table 1 Amino acids predicted to contribute to the interaction between RyR2 and vATPase

From: Inactive ryanodine receptors sustain lysosomal availability for autophagy by promoting ER-lysosomal contact site formation

RyR2

vATPase

ATP6v1a1

ATP6v1g1

ATP6v0a1

HIS681

GLY1474

GLU1731

GLN603

ILE8

ALA42

PRO248

HIS731

LYS1475

LYS1734

ASN610

LEU11

GLU45

GLU249

ALA738

VAL1476

SER1735

ALA611

LEU12

LYS56

THR250

ARG739

SER1479

SER1765

ARG613

GLU15

ALA57

PRO251

THR740

ILE1480

GLU1781

SER614

LYS16

LYS58

 

HIS747

LYS1481

PHE1782

 

ALA18

ALA60

 

ARG750

PRO1535

ASP1785

 

ALA19

ALA61

 

LEU1469

THR1730

GLU1837

 

VAL22

GLY64

 

LYS1473

   

SER23

SER65

 
    

GLU39

SER68

 
  1. The vATPase subunit to which each amino acid corresponds to is also indicated.
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