Fig. 4: Involvement of LR pairs based on neurodevelopmental ontologies and diseases. | Nature Communications

Fig. 4: Involvement of LR pairs based on neurodevelopmental ontologies and diseases.

From: Uncovering the molecular logic of cortical wiring between neuronal subtypes across development through ligand–receptor inference

Fig. 4

A Number of LR pairs predicted to be utilized per GABAN family as target cells, from E18 to adulthood. B Number of predicted LR interactions between IT and GABAN cell-types as source and target cells, respectively, from E18 to adulthood. C Percentage of LR pairs of five main neurodevelopmental ontologies and of the cadherin LR family that are predicted as utilized between IT and GABAN cell-types as source and target cells, respectively, from E18 to adulthood. D Percentage of LR pairs with both ligand and receptor associated with neurodevelopmental diseases that are predicted as utilized between IT and GABAN cell-types as source and target cells, respectively, from E18 to adulthood. E Intersections between LR pairs of the 4 diseases studied. F Interaction network showing the LR pairs associated with each disease. G Gene ontologies associated with inferred, disease-associated LR pairs. Associated source data are provided.

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