Table 2 Study of Drug-Related Adverse Events and Reported Lab Abnormalities

From: Intrathecal CRISPR-edited allogeneic IL-13Rα2 CAR T Cells for recurrent high-grade Glioma: preclinical characterization and phase I trial

Study of Drug-Related Adverse Events

No. of subjects (%)

CTCAE grading

Fever

4 (80)

1-2

Hypoxia

2 (40)

1-2

Vomiting

2 (40)

1-2

Headache

1 (20)

1

Reported Lab abnormalities

No. of subjects (%)

CTCAE grading

Increased CSF IL-6

5 (100)

NA

Increased CSF total protein

4 (80)

NA

Increased CSF lactate dehydrogenase

3 (60)

NA

Increased serum CRP

3 (60)

NA

Increased serum IL-6

2 (40)

NA

Lymphocyte count decreased

5 (100)

1-2

Leukocytosis

3 (60)

1-2

White blood cell decreased

1 (20)

1