Fig. 5: Sankey plot and enrichment analysis of top 100 metabolites associated with any NDD with sPLS (sparse partial least squares) model based on metabolome data of week 24 during pregnancy. | Nature Communications

Fig. 5: Sankey plot and enrichment analysis of top 100 metabolites associated with any NDD with sPLS (sparse partial least squares) model based on metabolome data of week 24 during pregnancy.

From: Longitudinal metabolome profiling from pregnancy through childhood and risk of neurodevelopmental disorders at age 10

Fig. 5: Sankey plot and enrichment analysis of top 100 metabolites associated with any NDD with sPLS (sparse partial least squares) model based on metabolome data of week 24 during pregnancy.The alternative text for this image may have been generated using AI.

Each left-side node represents a metabolite, and each right-side node represents a sub-pathway. All metabolites are uniquely assigned to one pathway. Node colors are arbitrarily assigned for visual clarity and do not reflect statistical significance or effect direction. All edges (links) have equal thickness and indicate membership relationships between metabolites and their respective pathways. Bubble plot displaying pathway-level enrichment statistics. Each point corresponds to one pathway. X-axis representing the enrichment magnitude of each pathway relative to metabolites. Y-axis: pathways with larger fold enrichment are plotted lower. Dot size: encodes p-value tier. One-sided P < 0.05 was considered significant, and raw P values were corrected for multiple testing using the FDR (false discovery rate) procedure across all tested sub-pathways. NDD neurodevelopmental disorder. Source data are provided as a Source data file.

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