Table 1 Optimization of tunable reaction conditions

From: Tunable enantioselective electrocatalytic functionalization of unactivated alkenes

  1. Unless otherwise specified, all reactions were performed by using racemic benzoxazolyl acetate 1a (0.1 mmol), alkene 2a (0.5 mmol), Ni(OAc)2·4H2O (10 mol%), L* (11 mol%), additive (10 mol%), 2,6-lutidine (0.1 mmol), nBu4NPF6 (0.1 M), DCE (0.5 mL) and TFE (2.5 mL) at 25 °C under constant-current conditions (2.0 mA, 4.5 F/mol) in an undivided cell. The enantiomeric excess (e.e.) was analyzed via high-performance liquid chromatography (HPLC). aAdditive (20 mol%), morpholine (0.1 mmol), nBu4NBF4 (0.1 M) in THF/TFE, 1.5 mA, 4.5 F/mol. b(TMS)3Si-H (0.5 mmol), 2a (2 mmol) in MeOH/TFE, 2.0 mA, 6.0 F/mol. c4a was isolated as the product with 26% yield and 92% e.e. Isolated yields after chromatography are shown. TFE, 2,2,2-trifluoroethanol; CF, carbon felt; nd, not detected.
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