Fig. 1: Annual incidence with age for individuals at high (PRS OR > 2), very high (PRS OR>3), and reduced risk (PRS OR < 0.5), compared to the population mean.
From: Preventing premature deaths through polygenic risk scores
Incidence data are based on US White Non-Hispanic self-reported race/ethnicity, and PRS effect sizes are based on European genetic ancestry (see Supplementary Information for figures based on alternative sources). Incidences are sex-averaged, apart from prostate cancer (male), breast cancer (female), and abdominal aortic aneurysm (male). Vertical dotted lines indicate the conventional screening start age. Horizontal dotted lines indicate the RAPs for different PRS-based risk groups. AAA abdominal aortic aneurysm, BC female breast cancer, CRC colorectal cancer, CAD coronary artery disease, HT hypertension, PC prostate cancer, T2D type 2 diabetes.
