Fig. 9: DNMT3B-mediated upregulation of SPAK promotes HCC progression. | Nature Communications

Fig. 9: DNMT3B-mediated upregulation of SPAK promotes HCC progression.

From: Targeting SPAK suppresses progression and averts an immune exhaustive microenvironment in hepatocellular carcinoma

Fig. 9: DNMT3B-mediated upregulation of SPAK promotes HCC progression.

DNMT3B-mediated hypermethylation of the SPAK gene body promotes the high expression of SPAK in HCC. SPAK directly phosphorylates GSK3β and inhibits the degradation of PD-L1 and c-Jun. Overall, the combination of monoclonal antibodies targeting the immune checkpoint PD-1 with the SPAK inhibitor ZT-1a might constitute a promising therapeutic strategy for treating HCC. A schematic diagram was designed using Adobe Illustrator.

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