Fig. 6: CD201 positive cells modulates vascular repair following an oxygen induced retinopathy injury.
From: Endothelial stem cells of the retinal vasculature reside in the optic nerve
a Scheme of experimental set-up for tamoxifen administration and lineage tracing in Procr[CD201]cre-ROSA26iDTR (ProcriDTR) mice at indicated time points following oxygen induced retinopathy. b Representative PECAM-1 stained OIR flat-mount retinas of ProcriDTR mice in OIR and controls at P28. Scale bars: 500 μm. In the top-right inset, neovascular tufts are shown in red and vascular obliteration in yellow. c Quantification of neovascular tufts and vascular obliteration of (b) (n = 12 in iDTR mice and n = 10 in ProcriDTR). CD201+ cells deletion resulted in more vascular obliteration. Data from at least 10 eyes and lines are presented as median. Significance was determined using two-tailed unpaired t test. Each image are from representative of at least two independent experiments. d Schematic illustration of the proposed stem cell system of retinal endothelial cells uncovered in this study.
