Fig. 6: Limited role of Elongin BC in restricting PRC2.1 targeting by EPOP in EpiLCs.
From: EPOP restricts PRC2.1 targeting to chromatin by directly modulating enzyme complex dimerization
a Heatmaps of ChIP-seq replicates. The differential MTF2 peaks between the EPOPWT and EPOPD5 EpiLCs were grouped into three categories based on the response to shRNA KD, using the FDR < 0.05 threshold. Differential peaks shared by the control and Elongin B KD are labeled as n1, differential peaks unique to the control KD are labeled as n2, and differential peaks unique to the Elongin B KD are labeled as n3. b Genome browser tracks of selected gene loci. Tracks were generated by SparK. Two gene loci associated with the shared differential MTF2 peaks between the control KD and the Elongin B KD are shown. c Venn diagram of the differential MTF2 peaks in the three categories.
