Fig. 2: Pan-neuronal knockdown of beat-Ia increases sleep duration without disrupting locomotor activity. | Nature Communications

Fig. 2: Pan-neuronal knockdown of beat-Ia increases sleep duration without disrupting locomotor activity.

From: Cross-species evidence for a developmental origin of adult hypersomnia with loss of synaptic adhesion molecules beat-Ia/CADM2

Fig. 2: Pan-neuronal knockdown of beat-Ia increases sleep duration without disrupting locomotor activity.

Sleep measures for flies expressing either an RNAi control or RNAi against beat-Ia in all neurons. A Total sleep duration across 24 h. B Activity index, which represents the number of infrared beam breaks per minute of waking activity. C Sleep trace depicts sleep amount (%) in rolling 30 min bins across day (ZT0-12, light) and night (ZT12-24, dark). D Average daytime sleep duration. E Average number of daytime sleep bouts. F Cumulative frequency plot of the relative frequency of daytime sleep bouts of increasing duration. G Average nighttime sleep duration. H Average number of nighttime sleep bouts. I Cumulative frequency plot of the relative frequency of nighttime sleep bouts of increasing duration. Sleep experiments were run with single-beam DAM monitors. One-way ANOVA with Dunnett’s multiple comparisons tests comparing experimental genotypes to control. n, from left to right = 46, 31, 30. *** p ≤ 0.001, **** p ≤ 0.0001. Each datapoint represents one animal. Bar plots display mean +/ SEM. Source data are provided as a Source Data file.

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