Fig. 3: Pan-neuronal knockdown of beat-Ia’s receptor, side, produces a long sleep phenotype. | Nature Communications

Fig. 3: Pan-neuronal knockdown of beat-Ia’s receptor, side, produces a long sleep phenotype.

From: Cross-species evidence for a developmental origin of adult hypersomnia with loss of synaptic adhesion molecules beat-Ia/CADM2

Fig. 3: Pan-neuronal knockdown of beat-Ia’s receptor, side, produces a long sleep phenotype.

A Schematic of the beat-side signaling pathway, illustrating how beat-Ia-expressing neurons follow a path of tissue (glia, muscle, neural, and epithelial) marked by its receptor side. Adapted from Siebert et al. 2009. B Total sleep duration across 24 h. C Sleep trace. D–G Day sleep measures. H–K Night sleep measures. Sleep experiments were run with single-beam DAM monitors. One-way ANOVA with Tukey’s multiple comparisons test comparing all genotypes to each other. n, left to right = 48, 47, 44. * p ≤ 0.05, ** p ≤ 0.01, *** p ≤ 0.001, **** p ≤ 0.0001. Each datapoint represents one animal. Bar plots display mean +/- SEM. Source data are provided as a Source Data file.

Back to article page