Fig. 5: beat-Ia acts in development to regulate adult sleep. | Nature Communications

Fig. 5: beat-Ia acts in development to regulate adult sleep.

From: Cross-species evidence for a developmental origin of adult hypersomnia with loss of synaptic adhesion molecules beat-Ia/CADM2

Fig. 5: beat-Ia acts in development to regulate adult sleep.The alt text for this image may have been generated using AI.

Day and night sleep duration (A) and sleep traces (B) from flies expressing beat-Ia RNAi under motor neuron drivers. Two-way ANOVA with Dunnett’s multiple comparisons tests comparing experimental genotypes to control. n, from left to right = 32, 31, 31, 32, 31, 28, 32, 31, 30. C Schematic of temporal restriction of beat-Ia knockdown using a temperature sensitive ubiquitously expressed GAL4 repressor (tubGAL80ts). Day and night sleep duration (D) and sleep traces (E) from flies in which neuronal beat-Ia is knocked down in development or adulthood. Sleep experiments were run with single-beam DAM monitors. Two-way ANOVA with Šídák’s multiple comparisons tests comparing experimental genotypes to control. n, from left to right = 52, 33, 10, 57, 38, 32. * p ≤ 0.05, ** p ≤ 0.01, **** p ≤ 0.0001. Each datapoint represents one animal. Bar plots display mean +/ SEM. Source data are provided as a Source Data file.

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