Table 1 Demographic characteristics of the IGNITE and AGUEDA cohort participants

From: Streamlined resource-efficient plasma amyloid-beta mass spectrometry assay has improved biomarker performance in preclinical Alzheimer’s disease

  

Dichotomized by a single cutoff

  

Trichotomized by two cutoffs

 

IGNITE cohort

 

Overall

Aβ-PET-negative§

Aβ-PET-positive§

p-value*

 

Aβ-PET-negative§

Aβ-PET-transition§

Aβ-PET-positive§

p-value*

Sample size

317

263

54

  

241

22

54

 

APOE ε4 carriership, n (%)

86 (27.1)

57 (21.7)

29 (53.7)

6.3E-6

 

46 (19.1)

11 (50)

29 (53.7)

3.2E-6

Age, mean (SD) years

69.5 (3.6)

69.3 (3.5)

70.4 (3.9)

0.05

 

69.4 (3.6)

68.7 (2.6)

70.4 (3.9)

0.129

Female sex, n(%)

229 (72.2)

191 (72.6)

38 (70.4)

1

 

180 (74.7)

11 (50)

38 (70.4)

1

MOCA score, mean (SD)

26.1 (2.5)

26.1 (2.6)

25.9 (2.4)

0.547

 

26.1 (2.6)

25.8 (1.9)

25.9 (2.4)

0.509

Education, mean (SD) years

16.3 (2.2)

16.3 (2.3)

16.4 (1.8)

0.976

 

16.3 (2.3)

16 (2.3)

16.4 (1.8)

0.927

Aβ-PET centiloid, mean (SD)

7.9 (29.0)

− 3.3 (10.3)

62.2 (29.6)

2.2E-16

 

− 5.1 (8.7)

17 (3.4)

62.2 (29.6)

2.2E-16

AGUEDA cohort

         
 

Overall

Aβ-PET-negative§

Aβ-PET-positive§

p-value*

 

Aβ-PET-negative§

Aβ-PET-transition§

Aβ-PET-positive§

p-value*

Sample size

76

64

12

  

58

6

12

 

APOE ε4 carriership, n (%)

12 (16.2)

7 (11.3)

5 (41.7)

0.029

 

7 (12.3)

0 (0)

5 (41.7)

0.025

Age, mean (SD) years

71.4 (3.9)

71.2 (4)

72.3 (3.1)

0.367

 

70.9 (4.0)

73.6 (3.6)

72.3 (3.1)

0.192

Female sex, n(%)

44 (57.9)

37 (57.8)

7 (58.3)

1

 

33 (56.9)

4 (66.7)

7 (58.3)

0.899

MOCA score, mean (SD)

25.8 (2.2)

25.8 (2.3)

25.7 (1.8)

0.834

 

25.7 (2.3)

26.5 (2)

25.7 (1.8)

0.71

MMSE score, mean (SD)

29 (1.1)

29 (1)

28.8 (1.7)

0.495

 

28.9 (1)

29.7 (0.5)

28.8 (1.7)

0.213

Education, mean (SD) years

11.7 (4.8)

11.8 (4.9)

11.2 (4.1)

0.694

 

11.5 (5)

14 (4.1)

11.2 (4.1)

0.457

Aβ-PET centiloid, mean (SD)

7.6 (25.3)

− 1.9 (9.8)

58.2 (22.3)

4.7E-8

 

− 3.70 (8.3)

16 (3)

58.2 (22.3)

1.1E-9

  1. Mean and Standard Deviation are reported for continuous variables. Frequencies and percentages are shown for categorical variables.
  2. § The diagnosis was performed by clinical diagnosis for the ADRC cohort, and Aβ PET neuroimaging for AGUEDA and IGNITE cohorts.
  3. * P-values were calculated using the two-sided Wilcoxon Rank Sum or Kruskal-Wallis tests for continuous variables, and two-sided Fisher’s exact test for a categorical variable.
  4. APOE apolipoprotein E; MMSE Mini Mental State Examination; MoCA Montreal Cognitive Assessment; CL Centiloid.
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