Table 7 Percent of variance in morning plasma AD biomarker levels explained by the neuro-glymphatic model over the null modela
From: The glymphatic system clears amyloid beta and tau from brain to plasma in humans
Condition and Predictor | Amyloid Status | Plasma Biomarker | Variance Explained | CI | P |
|---|---|---|---|---|---|
Sleep Condition PhysioS | Positive | All Biomarkers | 51.9% | 38.6% – 84.3% | 0.005 |
Ab40 | 49.1% | 22.4% – 92.8% | 0.027 | ||
Ab42 | 56.0% | 5.4% – 91.4% | 0.043 | ||
All Tau | 51.7% | 35.6% – 83.7% | 0.005 | ||
Negative | All Biomarkers | 91.1% | 47.4% – 98.1% | 0.013 | |
Ab40 | 97.8% | 45.5% – 99.6% | 0.015 | ||
Ab42 | 93.7% | 40.7% – 99.3% | 0.017 | ||
np-tau217 | 95.4% | 42.9% – 99.3% | 0.017 | ||
np-tau181 | 94.1% | 38.7% – 99.1% | 0.018 | ||
p-tau181 | 71.3% | 49.0% – 97.3% | 0.007 | ||
Sleep Condition HypnoS | Positive | All Biomarkers | 42.0% | 32.5% – 81.8% | 0.006 |
Ab40 | 57.7% | 16.1% – 91.4% | 0.032 | ||
Ab42 | 62.5% | 9.1% – 90.8% | 0.032 | ||
All Tau | 38.4% | 28.9% – 80.7% | 0.006 | ||
Negative | All Biomarkers | 87.4% | 17.7% – 96.9% | 0.020 | |
Ab40 | 95.7% | -30.1% – 98.3% | 0.081 | ||
Ab42 | 87.1% | -39.7% – 97.2% | 0.134 | ||
np-tau217 | 93.1% | 21.4% – 98.6% | 0.029 | ||
np-tau181 | 90.9% | 1.5% – 98.4% | 0.059 | ||
p-tau181 | 64.0% | 26.4% – 96.8% | 0.009 | ||
Sleep Deprivation/Wake PhysioW | Positive | All Biomarkers | 68.9% | 65.5% – 92.5% | 0.018 |
Ab40 | 76.6% | -7.9% – 94.1% | 0.092 | ||
Ab42 | -53.8% | −13.7% – 95.4% | 0.073 | ||
All Tau | 72.8% | 68.0% – 92.7% | 0.018 | ||
Negative | All Biomarkers | 85.1% | 34.9% – 98.0% | 0.020 | |
Ab40 | 92.5% | 40.2% – 99.4% | 0.019 | ||
Ab42 | 93.3% | 44.7% – 99.5% | 0.021 | ||
np-tau217 | 60.7% | −184.8% – 95.9% | 0.372 | ||
np-tau181 | 84.3% | −44.6% – 98.7% | 0.098 | ||
p-tau181 | 73.8% | 34.9%96.8% | 0.013 |
