Table 2 Incidences of HR-HPV infections in the participants who were negative for the corresponding HPV type at baseline

From: Variations in the Natural History of High-Risk HPV Types Following HPV-16/18 Bivalent Vaccination in Females Aged 18-45 Years

 

Vaccine group

Control group

HR (95%CI)

Original p value

FDR-adjusted q value

n/N*

Person-years at risk

Incidence (95%CI), per 1000 person-years

n/N*

Person-years at risk

Incidence (95%CI), per 1000 person-years

HPV type

HPV-16

102/3509

21439.8

4.8 (3.9, 5.8)

212/3485

21066.7

10.1 (8.8, 11.5)

0.48 (0.38, 0.60)

<0.0001

0.0007

HPV-18

57/3558

21955.7

2.6 (2.0, 3.4)

142/3528

21618.8

6.6 (5.6, 7.7)

0.40 (0.29, 0.54)

<0.0001

0.0007

HPV-31

67/3562

21917.3

3.1 (2.4, 3.9)

117/3545

21756.0

5.4 (4.5, 6.4)

0.57 (0.42, 0.77)

0.0003

0.0013

HPV-33

63/3558

21894.4

2.9 (2.2, 3.7)

86/3531

21767.6

4.0 (3.2, 4.9)

0.73 (0.53, 1.01)

0.0556

0.1205

HPV-35

55/3569

22010.4

2.5 (1.9, 3.3)

74/3546

21851.8

3.4 (2.7, 4.3)

0.74 (0.52, 1.05)

0.0877

0.1425

HPV-39

213/3545

21327.8

10.0 (8.7, 11.4)

170/3505

21367.1

8.0 (6.8, 9.2)

1.26 (1.03, 1.54)

0.0241

0.0627

HPV-45

18/3576

22167.0

0.8 (0.5, 1.3)

42/3550

22026.3

1.9 (1.4, 2.6)

0.43 (0.25, 0.75)

0.0027

0.0088

HPV-51

278/3522

21008.0

13.2 (11.8, 14.9)

242/3494

21090.9

11.5 (10.1, 13.0)

1.16 (0.98, 1. 38)

0.0852

0.1425

HPV-52

360/3397

19981.7

18.0 (16.3, 20.0)

336/3398

20193.6

16.6 (15.0, 18.5)

1.09 (0.94, 1.26)

0.2669

0.3855

HPV-56

162/3558

21555.7

7.5 (6.4, 8.8)

149/3515

21497.2

6.9 (5.9, 8.1)

1.09 (0.87, 1.36)

0.4515

0.4891

HPV-58

129/3543

21609.1

6.0 (5.0, 7.1)

145/3513

21488.0

6.7 (5.7, 7.9)

0.89 (0.70, 1.13)

0.3473

0.4515

HPV-59

87/3570

21853.1

4.0 (3.2, 4.9)

92/3541

21814.3

4.2 (3.4, 5.2)

0.95 (0.71, 1.27)

0.7174

0.7174

HPV-68

142/3553

21573.7

6.6 (5.6, 7.8)

155/3522

21509.3

7.2 (6.2, 8.4)

0.92 (0.73, 1.15)

0.4485

0.4891

HPV group

HPV-16/18

159/3586

22210.9

7.2 (6.1, 8.4)

354/3557

22105.8

16.0 (14.4, 17.8)

0.45 (0.37, 0.55)

<0.0001

0.0002

HPV-31/33/45

148/3587

22294.5

6.6 (5.7, 7.8)

245/3559

22221.6

11.0 (9.7, 12.5)

0.60 (0.49, 0.75)

<0.0001

0.0002

HR-HPV

1733/3587

22295.3

77.7 (74.2, 81.5)

1962/3559

22227.9

88.3 (84.5, 92.3)

0.89 (0.81, 0.97)

0.0068

0.0068

  1. HR-HPV high-risk human papillomavirus, HR hazard ratio, 95%CI 95% confidence interval, FDR false discovery rate.
  2. Bold values indicate statistical significance p < 0.05.
  3. For type-specific analyses, the standard Cox proportional hazards model was used. For HPV-16/18, HPV-31/33/45, and HR-HPV groups, the Wei-Lin-Weissfeld (WLW) Cox model was applied. A stratified Benjamini-Hochberg FDR procedure was used to adjust for multiple comparisons. All statistical tests were two-sided, with a significance level of α = 0.05.
  4. an, the number of events; N, the number of participants in the analysis set.
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