Fig. 3: Age-associated decline in cellular mechanotransduction within bone marrow tissue.
From: Mechanical rejuvenation of senescent stem cells and aged bone via chromatin remodeling
a Representative micro-CT assay (n = 6 biologically independent mice per group), b collagen I immunofluorescence staining and Masson staining (n = 8 biologically independent mice per group), c p-FAK immunofluorescence staining (green, n = 10 biologically independent mice per group), d immunohistochemistry for nuclear YAP localization (n = 10 biologically independent mice per group), e Lamin B immunofluorescence staining (red, n = 10 biologically independent mice per group), f immunohistochemistry for p16 (n = 8 biologically independent mice per group), g The p21 (n = 8 biologically independent mice per group), and h rH2A.X (n = 8 biologically independent mice per group) of bone marrow tissue in 20-month-old versus 2-month-old female C57BL/6J mice. Data are presented as mean ± SD. Scale bar, 500 μm for (b), 20 μm for (c–h). Two-sided Student’s t test was used. Exact P values and sample sizes (n) are provided. All raw data supporting the findings of this study are provided in Source data 3.
