Fig. 9: Proposed model illustrating the interplay between cellular traction force and cellular senescence.
From: Mechanical rejuvenation of senescent stem cells and aged bone via chromatin remodeling
This model highlights how intracellular traction forces modulate cellular senescence by influencing chromatin accessibility. Increased traction force promotes localized chromatin opening, facilitating FOXO1 activation and cellular rejuvenation. Conversely, reduced traction force leads to chromatin condensation, suppressing FOXO1 expression and accelerating senescence. Excessive traction force, however, induces DNA damage within open chromatin regions, exacerbating aging processes.
