Fig. 1: Study design. | Nature Communications

Fig. 1: Study design.

From: Identification of modifiable plasma protein markers of cardiometabolic risk in children and adolescents with obesity

Fig. 1: Study design.

Plasma proteomic profiles were measured using Olink Target 96 CVDII and INF panels in a cross-sectional study of 2377 children and adolescents with overweight/obesity and 1647 with normal weight. We assessed associations between circulating protein markers with age, sex, and overweight/obesity, as well as with cardiometabolic risk profiles. We evaluated the predictive performance of circulating protein biomarkers for detecting steatotic liver disease. Additionally, the Olink INF panel was measured in a subset of 184 children and adolescents undergoing non-pharmacological obesity treatment. We examined changes in INF proteins in response to BMI SDS reduction and investigated longitudinal associations between protein marker changes and cardiometabolic risk profiles. Created in BioRender. Stinson, S. (2025) https://BioRender.com/yloww5o. BMI body mass index, CVDII cardiovascular II, INF inflammation, SDS standard deviation score.

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