Fig. 2: Effect of the downstream mdr1 deletions on mdr1 mRNA expression. | Nature Communications

Fig. 2: Effect of the downstream mdr1 deletions on mdr1 mRNA expression.

From: A common DNA deletion altering the 3’UTR of mdr1 is associated with reduced mefloquine susceptibility in P. vivax parasites from Cambodian patients

Fig. 2: Effect of the downstream mdr1 deletions on mdr1 mRNA expression.

A Integrated Genome Viewer screenshot showing RNA-seq data mapping to the mdr1 locus from the P01 reference genome: the tracks show data from, top to bottom, a Cambodian isolate without the deletion, a Cambodian sample with the deletion, and the Salvador 1 strain. B Comparison of the normalized mdr1 expression between P. vivax isolates in which all clones carried the deletion (in blue, n = 61, min = 213.85, max = 1509.10, centre = 863.62, Q1 = 676.07, Q3 = 967.65, lower extreme=393.93, upper extreme = 1201.22) and isolates in which all clones have the non-deleted sequence (in yellow, n = 19, min = 129.29, max = 604.66, centre = 433.04, Q1 = 367.50, Q3 = 507.79, lower extreme = 300.01, upper extreme=604.66). We performed a two-sample unpaired t-test without adjustments for multiple comparisons (p = 7.568 × 10−11). The boxplot lines represent (from top to bottom) the first, second, and third quartiles, while the whiskers show the values within 1.5 times the interquartile range. Source data are provided as a Source Data file.

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