Fig. 2: Inhibitor-bound and GABA-bound states of hGAT3.
From: Structural basis for selective inhibition of human GABA transporter GAT3
Cryo-EM density maps of hGAT3 bound to a SR-THAP (blue map, contour level = 0.063 in ChimeraX), and b GABA (green map, contour level = 0.06 in ChimeraX). Lipid densities are shown in light yellow. c, d Surface representation of the inhibitor-bound and GABA-bound structures of hGAT3 viewed parallel to the membrane. c Slice view of hGAT3 showing the SR-THAP (orange) binding pocket. d Slice view of hGAT3 showing the GABA (green) binding pocket. The extracellular gating residues R75 (TM1 – blue) and D467 (TM10 – not shown), as well as P375 (EL4 – yellow) and F308 (TM6 – green), are shown as sticks in c, d.
