Fig. 6: Visual electrophysiology studies for ZIKV-exposed and control infants.
a Light-Adapted Electroretinogram (LA ERG) at 3 months. Waveforms shown are group averages (±SEM) of the left eye ERG recorded from a corneal electrode to monocularly-delivered 2.5 cd s m−2 white flashes on a 30 cd m−2 background following 10 min of light adaptation. b Flash visual evoked potential (FVEP) group averages (±SEM) at 3 months. FVEPs were recorded concurrently with the LA ERG. Waveforms shown are group averages of combined right and left occipital FVEPs following left eye stimulation. LA ERG and FVEP waveforms elicited by right eye stimulation are not shown as they were indistinguishable from those of the left eye. c Root mean square (RMS) amplitudes of the FVEP from left and right occipital sites. RMS amplitudes differed between groups at 3 months of age (Wilcoxon rank-sum test, p = 0.0023). d LA ERG group average waveforms (±SEM) at 12 months. e FVEP group average (±SEM) waveforms at 12 months. f FVEP RMS amplitudes for ZIKV-exposed became statistically indistinguishable from controls at 12 months (p = 0.52).
