Fig. 2: McB-mediated immune imprinting is subset specific.
From: Microbial activation of the GLP-2R mitigates gastrointestinal inflammation
A Study design. B Relative cecum sizes over time in response to antibiotics (ABX) treatment (gray shaded area, yellow dots), shown as fold-change (FC) compared to water groups. C Levels of small intestinal lamina propria FoxP3+RORγt+ peripherally induced regulatory T-cells (pTregs) over 2, 4, and 6 weeks. D Levels of large intestinal lamina propria pTregs over time. Levels of FoxP3-RORγt+ T-helper 17 (Th17) cells in small intestinal lamina propria after 2 (E), 4 (F), and 6 weeks (G), each with proportions of Th17 cells also expressing IL-10 or IFNγ. Levels of FoxP3-RORγt+ Th17 cells in large intestinal lamina propria after 2 (H), 4 (I), and 6 weeks (J) with levels of IL-10 and IFNγ-expressing cells. Data are presented as mean ± SEM with individual data points representing each mouse– the exact n-sizes are denoted within the bar of each experimental group. Statistical significance was determined by a Two-Way ANOVA with Fisher’s LSD multiple comparisons post hoc test. P < 0.05 was considered statistically significant and the exact p-values for the comparisons are shown on each plot. Created in BioRender. Choi, B. (2025) https://BioRender.com/3079cx6.
