Fig. 4: Human HD ILC1s prolong the survival of mice engrafted with human LSCs.

a Schematic illustration of the design and procedures for (b–d). 0.5 × 10⁴ human LSCs were sorted from the blood of AML patients were i.v. injected into NSG-SGM3 mice on day 0. One day later, 5 × 10⁴ human HD ILC1s were sorted from the blood of human healthy donors and i.v. injected into these mice. Three weeks later, the numbers of human CD34⁺CD38⁻ LSCs and CD45⁺CD33⁺ cells were analyzed. Images were created with Adobe Photoshop. b Summary data of the absolute cell number of human CD34⁺CD38⁻ LSCs in the blood of NSG-SGM3 mice (n = 5 individual mice). c Summary data of the absolute cell number of human CD45⁺CD33⁺ cells in the blood of NSG-SGM3 mice (n = 5 individual mice). d Survival of the mice transplanted with LSCs and treated without or with HD ILC1s isolated from PBMCs (n  = 5 individual mice in each group). Survival data were analyzed by Kaplan–Meier survival analysis and log-rank test. All non-survival data are shown as mean ± s.d. P values were calculated by two-taild Student’s t-test (b and c). Source data are provided as a Source Data file.