Fig. 9: The dual binding patterns of mammalian MBD2 and Cel-MBD-2. | Nature Communications

Fig. 9: The dual binding patterns of mammalian MBD2 and Cel-MBD-2.

From: Dual genomic localizations and gene regulatory functions of MBD-2 with and without NuRD in Caenorhabditis elegans which lacks DNA methylation

Fig. 9: The dual binding patterns of mammalian MBD2 and Cel-MBD-2.The alternative text for this image may have been generated using AI.

According to previous human and mouse studies, most MBD3 binding regions overlap with MBD2 and NuRD, but there are many unique MBD2 binding sites of high 5mC density (left). In a cytosine methylation-free context in C. elegans, we propose a model for the distribution of Cel-MBD-2 (right). Despite the absence of methylation in the C. elegans genome and the lack of methyl-binding domain in Cel-MBD-2, the dual binding patterns of Cel-MBD-2 are observed as in mammalian MBD-2, in which a small proportion of MBD-2 binds to open chromatin in association with NuRD complex and a large proportion binds to silent regions enriched with H3K27me3 and H3K9me2/3, independent of NuRD complex. The organism icons are created in BioRender. Zheng, C. (2025) https://BioRender.com/rfw8dhr.

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