Fig. 5: Risk stratification values of single-ancestry PGS methods across complex diseases. | Nature Communications

Fig. 5: Risk stratification values of single-ancestry PGS methods across complex diseases.

From: Comprehensive benchmarking single and multi ancestry polygenic score methods with the PGS-hub platform

Fig. 5: Risk stratification values of single-ancestry PGS methods across complex diseases.

Heatmap of the odds of being a case in the top 10% of PGS versus the odds of being a case in the bottom 10% or middle 20% of the PGS distribution for each method across 19 diseases. The values correspond to risk-stratification levels. PsO psoriasis, SCZ schizophrenia, PCa prostate cancer, CD Crohn’s disease, SLE systemic lupus erythematosus, BCa breast cancer, CAD coronary artery disease, PD Parkinson’s disease, HF heart failure, LCa lung cancer, COPD chronic obstructive pulmonary disease, T2D type 2 diabetes, RA rheumatoid arthritis, VTE venous thromboembolism, BP bipolar disorder, POAG primary open-angle glaucoma. Analyses were conducted in the UK Biobank European testing cohort (N = 188,745). Rows correspond to diseases, and columns correspond to single-ancestry PGS methods.

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