Fig. 6: Age-group specific spaceflight effects. | Nature Communications

Fig. 6: Age-group specific spaceflight effects.

From: MiRNAs shape mouse age-independent tissue adaptation to spaceflight via ECM and developmental pathways

Fig. 6: Age-group specific spaceflight effects.The alternative text for this image may have been generated using AI.

a Sample counts for each age group (3 months and 8 months) for each tissue split by condition, flight (FL), habitat ground control (HGC) and vivarium ground control (VGC) for the live animal return (LAR) group only. b Comparison of variance explained by condition and age for tissues from the group. Note, the brain was not included as we only have samples from the 3-month group. Source data are provided as a Source Data file. c Correlation between miRNA fold-changes of FL vs. HGC across the age groups 3 months, 8 months, and all ages. Significant correlations (adj. P value < 0.05, two-sided test, abs. Pearson’s correlation >0.5, BH adjustment) are shown with a dot. Source data are provided as a Source Data file. d Effects of spaceflight on the different age groups. SCAT and Liver correspond to examples of tissues with the highest correlation between miRNA fold-changes (Pearson’s R value = 0.65 and 0.62, see Fig. 6c), while MAT and diaphragm correspond to tissues with the lowest correlation (Pearson’s R value of = −0.29 and −0.40, see Fig. 6c). Source data are provided as a Source Data file.

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