Fig. 4: Transcriptomic profiling reveals PLpro-mediated immune suppression and YL1004-induced restoration of antiviral gene expression. | Nature Communications

Fig. 4: Transcriptomic profiling reveals PLpro-mediated immune suppression and YL1004-induced restoration of antiviral gene expression.

From: YL1004 is a SARS-CoV-2 papain-like protease inhibitor with immunomodulatory and antiviral activity in mice

Fig. 4: Transcriptomic profiling reveals PLpro-mediated immune suppression and YL1004-induced restoration of antiviral gene expression.

a Heatmap of representative genes significantly regulated by YL1004 with/without PLpro expression in the context of poly(I:C). b GO enrichment analysis of genes downregulated by PLpro. c GO enrichment analysis of genes upregulated by YL1004. Data were obtained from two biological replicates.

Back to article page