Fig. 3: Phenotypes related to APOE-associated SNPs in the NIH All of Us dataset.
From: A common 19 bp APOE enhancer deletion is protective against Alzheimer’s disease in African Americans
a–c Phenome-wide association study (PheWAS) Manhattan plot for 1816 traits grouped into related categories on the x-axis compared with significance on the y-axis for a, rs429358 (the APOE-ε4 defining SNP), b rs7412 (the APOE-ε2 defining SNP) and c rs148353395 (the 19 bp deletion). d Forest plot of the PheWAS odds ratio, standard error, and whether Bonferroni significance was reached for the conditions which passed Bonferroni significance for at least the APOE-ε4 or APOE-ε2 defining SNP and had at least 50 cases for rs7412 (green), rs429358 (blue), and rs148353395 (yellow). Also shown are the odds ratio for rs148353395 after adjusting for rs7412 and rs429358 (in purple) and for rs429358 after adjusting for rs148353395 (in red). Significance is denoted by a filled square for conditions which passed Bonferroni correction (p < 2.75 × 10-5), nominal significance (p < 0.05) with a filled triangle, and an unfilled circle for conditions which did not reach significance. The n for each trait and variant can be found in Supplementary Data 1-5. Delirium dementia*: full phenotype name is: “Delerium dementia and amnestic and other cognitive disorders”. Source data are provided as a Source Data file.
