Fig. 5: PheWAS analysis of intergenic variants between APOE and APOC1 from NIH All of Us.
From: A common 19 bp APOE enhancer deletion is protective against Alzheimer’s disease in African Americans
a Pairwise linkage disequilibrium (LD) plot of Pearson correlation (r2) between SNPs present in the intergenic region between APOE and APOC1 with a minor allele frequency of >1% and >0.2 r2 in samples of African ancestry (n = 32,886 individuals). b LD map for the same SNPs in samples of European ancestry (n = 104,107 individuals). c Manhattan PheWAS multi-ancestry plot for rs438811. d Corresponding forest plot of odds ratios and standard error for rs438811 of the top 20 most significant phenotypes. e Manhattan plot for rs72654473. f Corresponding forest plot of odds ratios and standard error for rs72654473 of the top 20 most significant All of Us phenotypes. All values and ns available in Supplemental Tables 19 and 21.
