Table 2 Odds of developing AD or hyperlipidemia for SNPs across APOE-APOC1 in NIH All of Us data

From: A common 19 bp APOE enhancer deletion is protective against Alzheimer’s disease in African Americans

Disease

  

Alzheimer’s disease (n = 656)

  

Hyperlipidemia (n = 102606)

  

SNP

MAF

chr19 position

OR

SE

p

OR

SE

p

rs429358

0.145

44908684

2.730

0.065

2.00E-53

1.210

0.010

1.00E-91

rs7412

0.077

44908822

0.550

0.131

5.00E-06

0.710

0.013

4.00E-160

rs1081105

0.027

44909698

2.250

0.129

3.00E-10

1.190

0.021

3.00E-17

rs1065853

0.055

44909976

0.500

0.165

2.00E-05

0.710

0.015

5.00E-114

rs148353395

0.029

44910531

1.320

0.206

0.173

1.180

0.023

4.00E-13

rs1081106

0.067

44910109

0.800

0.117

0.051

1.060

0.014

6.00E-05

rs72654471

0.032

44910852

0.799

0.215

0.297

0.991

0.021

0.657

rs72654473

0.109

44911142

0.890

0.094

0.225

0.810

0.011

7.00E-79

rs439401

0.636

44911194

1.220

0.061

0.001

1.050

0.007

7.00E-10

rs138235833

0.034

44912028

1.062

0.14

0.67

0.966

0.019

0.066

rs445925

0.133

44912383

0.944

0.087

0.509

0.863

0.01

4.90E-47

rs10414043

0.123

44912456

2.345

0.071

1.52E-33

1.142

0.01

2.16E-38

rs7256200

0.123

44912678

2.342

0.071

2.04E-33

1.143

0.01

1.72E-38

rs483082

0.25

44912921

1.683

0.061

2.03E-17

0.987

0.008

0.103

rs59325138

0.35

44913034

0.753

0.061

3.18E-06

1.054

0.007

1.47E-13

rs584007

0.639

44913221

1.212

0.061

1.59E-03

1.047

0.007

3.58E-10

rs438811

0.259

44913484

1.730

0.061

4.00E-19

0.990

0.008

0.305

rs390082

0.136

44913574

0.975

0.086

7.68E-01

0.867

0.01

3.18E-45

rs11568822

0.214

44914383

1.670

0.062

1.00E-16

0.960

0.008

8.00E-06

  1. SNP single nucleotide polymorphism, MAF minor allele frequency, OR odds ratio, SE standard error.