Fig. 6: Impact of Olig2 on the transcriptome of Ngn2-transduced astrocytes.
From: Olig2 acts as an inducible barrier to in vivo astrocyte-to-neuron conversion
a The top cartoon illustrating the origin of the two DEGs datasets. Created in BioRender.com. Hou, KY. (https://BioRender.com/j2p0bx9). The common and unique DEGs were shown in the Venn diagram at the bottom. b Bar chart showing the top GO-BP enriched pathways unique to Ngn2-overexpressing astrocytes without knockdown of Olig2. c Bar chart showing the top GO-BP enriched pathways specific to Ngn2-overexpressing astrocytes with Olig2 downregulation. d The Venn diagram showed four different regulatory patterns of 367 common DEGs, representing that Olig2 exerted a profound effect on the regulation of gene expression in Ngn2-overexpressing astrocytes. Chord diagram showing the genes and enriched GO pathways for Pattern 1 (e), Pattern 2 (f), Pattern 3 (g), and Pattern 4 (h), respectively.
