Fig. 1: Schematic of the design of MSC-laden CPAC hydrogel for the treatment of critical-sized rat cranial bone defects. | Nature Communications

Fig. 1: Schematic of the design of MSC-laden CPAC hydrogel for the treatment of critical-sized rat cranial bone defects.

From: Mechanically heterogeneous hydrogel with cell-programmed network restructuring promotes tissue regeneration by mechano-epigenetic modulation

Fig. 1: Schematic of the design of MSC-laden CPAC hydrogel for the treatment of critical-sized rat cranial bone defects.The alternative text for this image may have been generated using AI.

a Schematic showing the natural ECM network changed from homogeneous to heterogeneous during skull development. b Schematic showing the network heterogenization of MSCs-laden NC hydrogel (left), NCLS hydrogel (middle), and CPAC hydrogel (right) after ALP exposure. c Mechanism of heterogeneous network formation induced by ALP-mediated phase transition in CPAC hydrogels. d Proposed signaling pathways involved MSC-driven active remodeling of the extracellular matrix and enhanced osteogenesis.

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