Fig. 4: Multicomponent synergistic anti-tumor activity of protein⊂ZPF-2 with different distribution of proteins. | Nature Communications

Fig. 4: Multicomponent synergistic anti-tumor activity of protein⊂ZPF-2 with different distribution of proteins.

From: Multicomponent synergistic immobilization via in-situ and dynamic exchange strategies for constructing hierarchical biopharmaceuticals

Fig. 4: Multicomponent synergistic anti-tumor activity of protein⊂ZPF-2 with different distribution of proteins.

a Illustration of the synthesis of GOx@Tf⊂ZPF-2 (Tf = transferrin). b PXRD patterns of GOx@Tf⊂ZPF-2, GOx@ZPF-8, GOx@ZPF-2, calculated ZPF-2, and calculated ZPF-8. c SIM images of GOx@Tf⊂ZPF-2. Each experiment was independently repeated three times, and the results were all similar. d Cytotoxicity of protein@ZPF-2 toward HeLa cells. 1: Tf⊂ZPF-2; 2: GOx@ZPF-2; 3: GOx&Tf@ZPF-2; 4: GOx@Tf⊂ZPF-2; 5: Tf@GOx⊂ZPF-2. IC50: 90.00, 66.79, 57.72, 39.77, and 66.64 μg/mL. e Cytotoxicity of protein@ZPF-2 toward HeLa cells. I: Tf⊂ZPF-2; II: GOx@Tf⊂ZPF-2; III: GOx&5-FU@Tf⊂ZPF-2 (5-FU = 5-fluorouracil). All error bars mean ± s.d. received from three independent experiments (n = 3 independent experiments). The significance was calculated by one-way ANOVA using Tukey’s multiple comparisons test. ****p  <  0.0001.

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