Fig. 1: Spatial distribution and genomic diversity of S. aureus isolates in the NICU setting. | Nature Communications

Fig. 1: Spatial distribution and genomic diversity of S. aureus isolates in the NICU setting.

From: Rapid dissemination of Staphylococcus aureus in the neonatal intensive care unit is associated with invasive infection

Fig. 1: Spatial distribution and genomic diversity of S. aureus isolates in the NICU setting.The alt text for this image may have been generated using AI.

a NICU floorplan visualization of S. aureus methicillin-resistant (MRSA)/S. aureus methicillin-susceptible (MSSA) surveillance results: positive S. aureus colonizing samples (blue dots, size proportional to frequency) and S. aureus bacteremia samples (red crosses). b Core-genome maximum likelihood phylogeny annotated with sample source (outer ring, red: invasive, blue: colonizing, gray: environmental) and clonal complexes (CC) assignment (bars and text labels). Genomes assigned to CC 1, 5, and 8 were paraphyletic in the phylogenetic analysis. Branch colors indicate bootstrap support, with values ≥ 70 supporting 66.4% of branches. c Pair-wise SNP analysis reveals clonal relationships among S. aureus genomes by comparing genomes across three datasets: (1) within NICU genomes (NICU), (2) against a local Philadelphia pediatric database (Local), and (3) against a curated global publicly available database (Global). d Monthly MSSA/MRSA colonization and infection rates. Colonization rates are calculated as a percentage of colonized patients among sampled patients, and infection rates are calculated as BSIs per 1000 patient-days. Both colonization and infection rates were significantly higher for MSSA than for MRSA. e Workflow schematic for identifying strains, clones, and transmission clusters. Red boxes represent decision points, while blue boxes indicate process outputs, serving as inputs for subsequent analytical steps. Source data are provided as a Source Data file.

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