Fig. 6: Proposed catalytic and inhibitory mechanism of FKS.
From: Inhibition mechanism of the fungal β−1,3-glucan synthases by triterpenoid antifungal drugs
With the help of Rho, FKS catalyzes the initiation and elongation of glucan by conformational change between the basal and open states. EFU inhibits FKS by fixing the enzyme specifically in the basal state. More details are provided in the text.
