Fig. 5: Evaluation of GOx/SOD-BC dressing for chronic wound healing in a db/db mouse model.

a Schematic illustration of the GOx/SOD-BC dressing, its application process, and the timeline for creating and treating wounds in the animal model. b Representative photographs of wound progression at days 0, 3, 5, 7, and 14 (scale bar: 1 cm). The experiment was repeated three times independently and yielded comparable results. c, d Quantitative analysis of wound area changes among the control, gauze, BC, and GOx/SOD-BC groups (n = 3 per group). e H&E-stained histological sections of wound tissue in each group on day 14 (Red arrows: new vessels; yellow arrows: sebaceous gland (SG); blue arrows: hair follicle (HF). Scale bar: 1 mm and 200 μm). The experiment was repeated three times independently and yielded comparable results. f Measured dermal thickness in the different treatment groups (n = 3 per group; statistical significance was determined using one-way ANOVA; **p < 0.01). g Masson’s trichrome-stained sections of wound tissue on day 14, highlighting collagen distribution (scale bar: 1 mm and 200 μm). The experiment was repeated three times independently and yielded comparable results. h Percentage of collagen deposition in each group (n = 3 per group; statistical significance was determined using one-way ANOVA; **p < 0.01). Data are presented as mean ± SD. Source data for this figure is available in the Source Data file.