Fig. 9: Proposed mechanistic models of R2SP and R2TP assembly. | Nature Communications

Fig. 9: Proposed mechanistic models of R2SP and R2TP assembly.

From: An integrative structural biology approach reveals the dynamic organization of the R2SP quaternary chaperone complex

Fig. 9: Proposed mechanistic models of R2SP and R2TP assembly.

A R2SP assembly is proposed to involve cooperativity between SPAG1 and PIH1D2 as they engage RUVBL1/RUVBL2. B R2TP assembly is proposed to involve independent binding of RPAP3 and PIH1D1 to RUVBL1/RUVBL2. In both panels, the position of the pointer on the counter represents the rate of ADP release.

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