Fig. 1: scRNA-seq based characterisation of cutaneous B cells. | Nature Communications

Fig. 1: scRNA-seq based characterisation of cutaneous B cells.

From: Indolent primary cutaneous B-cell lymphomas resemble persistent antigen reactions without signs of dedifferentiation

Fig. 1: scRNA-seq based characterisation of cutaneous B cells.

a Schematic overview of all cutaneous samples and UMAP embedding of the respective scRNA-seq data. Created in BioRender. Griss, J. (2026) https://BioRender.com/33vew3u. b UMAP embedding of the subclustered B cells (including B, and Plasma cells) of all cutaneous samples. c Dot plot of key B cell markers used to identify respective B-cell subtypes. Colour intensity represents average expression and point size the fraction of expressing cells. d UMAP embedding of the subclustered B cells highlighting the results of the BCR sequencing. Colours represent the top-expanded clone of all samples per disease. e Frequency of B-cell subtypes per disease shown for all B cells (top) and only B cells part of the top-expanded clone (bottom). f UMAP embedding of the B cell subclustering highlighting the results of the monocle3-based pseudotime analysis. Black lines represent the identified trajectories. g Pseudotime of each individual cell from the top-expanded clone in pcMZL per sample. Colours represent the identified B-cell subtypes. h Frequency of B-cell subtypes of the top expanded clone from one patient with pcFCL and one patient with pcDLCBL-LT from the study of Ramelyte et al. Source data are provided as a Source Data file.

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