Fig. 1: Differential methylation in NEPC compared to PRAD. | Nature Communications

Fig. 1: Differential methylation in NEPC compared to PRAD.

From: Crosstalk between EZH2 and DNA methylation mediates neuroendocrine prostate cancer lineage plasticity

Fig. 1: Differential methylation in NEPC compared to PRAD.

A Volcano plot showing differentially methylated regions (DMRs) in PRN NEPC tumors (n = 2) compared to PRN PRAD tumors (n = 2) highlighting common DMR-associated genes from patient CRPC tumors (NEPC and PRAD). B Volcano plot showing differentially methylated regions (DMRs) in NEPC PDOs (n = 3; MSKPCa10, MSKPCa4 and WCM154) compared to PRAD PDOs (n = 2; WCM1358 and MSKPCa2) highlighting common DMRs from patient CRPC tumors (NEPC and PRAD). C Pathway analysis of enriched gene sets for genes associated with hypo- and hyper-methylated regions in PRN NEPC tumors (n = 2) using GSEA. The False Discovery Rate (FDR) q value was calculated using the default permutation-based method in GSEA. D Pathway analysis of enriched gene sets for genes associated with hypo- and hyper-methylated regions in NEPC PDOs (n = 3; MSKPCa10, MSKPCa4 and WCM154) compared to PRAD PDOs (n = 2; WCM1358 and MSKPCa2) that are common with DMRs from patient CRPC tumors (NEPC and PRAD) using GSEA. The False Discovery Rate (FDR) q value was calculated using the default permutation-based method in GSEA.

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