Fig. 2: Structurally assessment of Api m 1/nanobody complexes. | Nature Communications

Fig. 2: Structurally assessment of Api m 1/nanobody complexes.

From: Nanobody-based IgG simultaneously inhibit the allergenic and enzymatic activity of the dominant honeybee venom allergen

Fig. 2: Structurally assessment of Api m 1/nanobody complexes.

a, b Cartoon representation with transparent surface of the nanobodies AM1-1 (green) and AM1-4 (blue) binding two distinct epitopes on opposing sides of Api m 1 (orange). c, d Api m 1 with bound nanobody (left). Api m 1 residues that interact with the nanobodies by direct hydrogen bonds are colored green (AM1-1) and blue (AM1-4) (right). e Api m 1 sequence with secondary structures (orange; arrow: β-strand, cylinder: α-helix). Residues interacting with AM1-1 and AM1-4 by direct hydrogen bonds are highlighted.

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