Fig. 7: Role of H3K4me1 in animals and plants.
From: H3K4me1 directs H3K36me2 and H3K36me3 deposition in land plants
Upper panel: In animals, H3K4me1 marks various enhancer states. Within a given tissue, a subset of poised enhancers are characterized by H3K4me1 and H3K27me3. Prior to activation, enhancers existing in a primed state marked only with H3K4me1. Active enhancers, which lack nucleosomes, are adjacent to nucleosomes marked with H3K4me1 and H3K27ac. Specific transcription factors link the active enhancers and target genes, mediated by cohesin and other protein complexes. Lower panel: In plants, H3K4me1 directs the establishment of H3K36me2/me3. The tandem plant homeodomain (PHD) finger domain-containing protein Ehd3 specifically recognizes H3K4me1 and interacts with the H3K36 methyltransferase SDG724. This interaction stimulates the catalytic activity of SDG724, facilitating the deposition of H3K36me2/me3, which results in the colocalization of H3K4me1 and H3K36me2/me3 in plants.
