Fig. 4: Age effects in subtype 1 and subtype 2 aligned with two functional hierarchical axes.

Specifically, age effects in subtype 1 follow the motor/auditory-visual axis (r = 0.44, pspin < 0.001) and in subtype 2 follow the sensory-association axis (r = 0.58, pspin < 0.001). Each point on the scatter plot (N = 400) indicates one parcel in the Schaefer 400 parcellation. Statistical significance was accessed using spin permutation of each group’s age effect map (Schaefer 400 parcellation, 1000 repetitions), respectively. Source data are provided as a Source Data file.