Fig. 1: GSNOR KO mice exhibit resistance to age-related obesity. | Nature Communications

Fig. 1: GSNOR KO mice exhibit resistance to age-related obesity.

From: S-nitrosoglutathione reductase GSNOR drives age-related obesity by promoting adipose tissue whitening through de-nitrosation of Beclin-1

Fig. 1: GSNOR KO mice exhibit resistance to age-related obesity.The alternative text for this image may have been generated using AI.

a Body weight of male WT and KO mice during aging (WT n = 19, KO n = 11). b Body weight of female WT and KO mice during aging (WT n = 20, KO n = 16). c Gross view, fat and lean mass percentage of 11-month-old male WT and KO mice, as determined by magnetic resonance imaging (MRI) (n = 8). d Gross view, fat and lean mass percentage of 20-month-old male WT and KO mice, as determined by MRI (n = 5). e, f Gross view and weight percentage of iWAT, gWAT, and BAT relative to body weight from 11-month-old male WT and KO mice (WT n = 9, KO n = 11). g, h Gross view and weight percentage of iWAT, gWAT, and BAT relative to body weight from 20-month-old male WT and KO mice (n = 10). i H&E staining and cell number per view of iWAT, gWAT, and BAT from 20-month-old male WT and KO mice (n = 10). Scale bar, 100 μm. Data are represented as mean ± SEM (a, b) or mean ± SD (c, d, f, h, i); Significance was assessed by Unpaired two-tailed Student’s t test (a, b, c, d, f, h, i) (*p < 0.05, **p < 0.01, ***p < 0.001, ns for not significant). WT wild-type, KO, GSNOR knockout, MRI magnetic resonance imaging, H&E hematoxylin and eosin, iWAT inguinal white adipose tissue, gWAT gonadal white adipose tissue, BAT brown adipose tissue.

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